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SGLT2 Have you taken any of the following medications for Type 2 Diabetes?
 Brand Name  Active Ingredient(s)
 Invokana  canagliflozin
 Invokamet  canagliflozin and metformin
 Invokamet XR  canagliflozin and metformin extended-release
 Farxiga  dapagliflozin
 Xigduo XR  dapagliflozin and metformin extended-release
 Qtern  dapagliflozin and saxagliptin
 Jardiance  empagliflozin
 Glyxambi  empagliflozin and linagliptin
 Synjardy  empagliflozin and metformin
 Synjardy XR  empagliflozin and metformin extended-release
 Steglatro  ertugliflozin
 Segluromet  ertugliflozin and metformin
 Steglujan  ertugliflozin and sitagliptin
  These drugs, known as SGLT2 inhibitors, are used in conjunction with diet and exercise to lower blood sugar in adults with type 2 diabetes. Unfortunately, the FDA has linked these medications with a life-threatening genital infection called FOURNIER’S GANGRENE. From (
The U.S. Food and Drug Administration (FDA) is warning that cases of a rare but serious infection of the genitals and area around the genitals have been reported with the class of type 2 diabetes medicines called sodium-glucose cotransporter-2 (SGLT2) inhibitors. This serious rare infection, called necrotizing fasciitis of the perineum, is also referred to as Fournier’s gangrene.
Known as “flesh-eating disease” or “flesh-eating bacteria,” necrotizing fasciitis is a life-threatening bacterial infection of the tissue under the skin that surrounds muscles, nerves, fat, and blood vessels of the perineum. The bacteria may enter the body through a break in the skin, where they quickly spread and destroy the infected tissue. The condition must be treated immediately because it may severely damage the tissues around the genital area. Dozens of patients have been diagnosed with this condition after using SGLT2 inhibitor medications. In the five years between March 2013 and May 2018, the FDA identified 12 patients who developed Fournier’s gangrene within several months of starting an SGLT2 inhibitor. All 12 patients were hospitalized and required surgery. Some of the patients developed severe complications, others necessitated multiple disfiguring surgeries, and one patient died. In comparison, over a period of more than 30 years, the FDA identified only six cases of Fournier’s gangrene when reviewing other antidiabetic drug classes.  


  1. SEEK MEDICAL ATTENTION IMMEDIATELY if you are taking an SGLT2 inhibitor and you experience any symptoms of tenderness, redness, or swelling of the genitals or the area from the genitals back to the rectum, and have a fever above 100.4 F or a general feeling of being unwell. ( 2. SAVE YOUR PRESCRIPTION BOTTLE/PRINTOUT.  

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